Blar i forfatter "Niere, Marc"

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    • Identification of evolutionary and kinetic drivers of NAD-dependent signaling 

      Bockwoldt, Mathias; Houry, Dorothee; Niere, Marc; Gossmann, Toni I.; Reinartz, Ines; Schug, Alexander; Ziegler, Mathias; Heiland, Ines (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-24)
      Nicotinamide adenine dinucleotide (NAD) is best known as an essential cofactor of biochemical reactions. In addition, it is involved in the regulation of virtually all major cellular events. These NAD-dependent regulatory functions are mediated by enzymes (e.g., sirtuins, poly–adenosine -diphosphate [ADP] ribose polymerases, ADP-ribosyl cyclases) that cleave the molecule to liberate nicotinamide ...

    • Keeping the balance in NAD metabolism 

      Strømland, Øyvind; Niere, Marc; Nikiforov, Andrey; Van Linden, Magali R; Heiland, Ines; Ziegler, Mathias (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-09)
      Research over the last few decades has extended our understanding of nicotinamide adenine dinucleotide (NAD) from a vital redox carrier to an important signalling molecule that is involved in the regulation of a multitude of fundamental cellular processes. This includes DNA repair, cell cycle regulation, gene expression and calcium signalling, in which NAD is a substrate for several families of ...